Phosphine Toxicological overview
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چکیده
Inhaled phosphine is absorbed rapidly from the lungs and distributed round the body Inhaled or ingested zinc, aluminium and magnesium phosphides release phosphine into the respiratory tract and stomach; zinc phosphide can be absorbed intact from the gut Dermal absorption of phosphine or phosphides is not considered a significant route of exposure The majority of absorbed phosphine is excreted in exhaled air; minor amounts are metabolised and excreted in urine as hypophosphite and phosphate
منابع مشابه
Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans.
The aim of this study is to identify the biochemical mechanism of phosphine toxicity and resistance, using Caenorhabditis elegans as a model organism. To date, the precise mode of phosphine action is unclear. In this report, we demonstrate the following dose-dependent actions of phosphine, in vitro: (1) reduction of ferric iron (Fe3+) to ferrous iron (Fe2+), (2) release of iron from horse ferri...
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